California’s Leading Health Data Utility
Delivering real-time data that powers healthcare transformation

As the largest nonprofit health data network in California, Manifest MedEx (MX) is an integral part of the state’s health data infrastructure, combining and delivering crucial health information for more than 38 million Californians across every county throughout the state.

3200+

CA Healthcare organizations

140+

Hospitals

19

health plans

50 Million

Individual Records

MX is taking bold steps toward health transformation, working with partners on the local, state, and national level to address health equity challenges and support population health management initiatives. As the only non-profit QHIO in CA that can help organizations participate in both the Data Exchange Framework (DxF) and the Trusted Exchange Framework and Common Agreement™ (TEFCA) — regardless of their location, technical capabilities, or resources — we are committed to advancing CalAIM and DxF goals by improving efficiency and outcomes and enabling whole person care. 

With the California ADT Network, MX is creating a digital health safety net by enabling hospitals, health systems, skilled nursing facilities, and QHIOs participating in the DxF to securely send and receive basic ADT notifications for free to improve patient care and help meet DxF data sharing requirements.

Health Plans

Participate alongside California’s leading health plans in using data to care for millions of members. With the MX network, health plans can improve efficiency and member experience with faster, more informed care coordination, identify and resolve care gaps, manage population health, and streamline HEDIS reporting with NCQA-validated data.

Hospitals

Join more than 140+ participating California hospitals on the network today. With immediate access to real-time notifications, longitudinal health records, and valuable insights on usage and leakage patterns, MX helps hospitals reduce readmissions, improve care coordination, efficiently manage networks, and easily meet new CMS ADT requirements.

Providers

Succeed in value-based care with a powerful data connection across the state. Longitudinal and real-time MX data delivered straight to more than 2,600 ambulatory providers helps clinicians save time, succeed in risk-based contracts, and provide coordinated, person-centered care to patients.

Counties and Public Health

Achieve whole person care and community health goals with MX’s real-time alerts, longitudinal patient records including SDOH data, and comprehensive analytics that can be used to identify and target high risk populations so that those most vulnerable get the care they need, when they need it.

Why Manifest MedEx?

We are a California network with national connectivity, exchanging health data with national and regional networks, so that participants can share data across a broad healthcare ecosystem. And we go beyond just the secure delivery of reliable and accurate health data to ensure that the information is ready to bring value to your clinicians and patients.

Explore the suite of MX solutions available to every participant, which includes direct data feeds, NCQA Validated data streams, and access to our applications.

MX Notify

Receive real-time hospital admit, discharge, and transfer (ADT) information on your patients when they need help the most. Through flexible integrations with more than 70+ EMR and other technology systems, MX Notify conveniently brings one of the most powerful health data tools to your teams.

 

Explore MX Notify

MX Access

View detailed longitudinal health records for your patients, including recent encounters, allergies, medications, lab results, vaccination status, COVID status, and others — all from the largest health data network in California.

 

Explore MX Access

MX Analyze

Utilize powerful public health and population risk management tools that turn MX data into actionable insights. Easy-to-use analytics help you to understand more about your patient population, identify your highest risk segments to target for interventions, and succeed in risk-based contracts.

 

Explore MX Analyze

News and Case Studies

Manifest MedEx and SCHIO Announce Strategic Affiliation To Connect California and Advance Statewide Health and Social Services Data Infrastructure

Collaboration will accelerate seamless, secure whole person data sharing to empower healthier communities in Bay Area and across state [Riverside, Calif., and Santa Cruz, Calif. – BUSINESS WIRE – October 22, 2025] Manifest MedEx (MX) and Serving Communities Health Information Organization (SCHIO), two of California’s most respected nonprofit health data networks and Data Exchange Framework…

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Manifest MedEx Applauds Governor Newsom for Signing SB 660 to Strengthen California’s Data Exchange Framework

Riverside, CA – (BUSINESS WIRE) – October 8, 2025 – Manifest MedEx, California’s largest nonprofit health data network, today celebrated Governor Gavin Newsom for signing SB 660, new legislation introduced by Senate Health Committee Chair, Caroline Menjivar, that reinforces accountability and participation in California’s Data Exchange Framework (DxF). The DxF is a cornerstone of California’s…

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Health Data Exchange Drives Efficiency and Cuts Costs

With California’s Data Exchange Framework constantly evolving, the California Health Care Foundation (CHCF) initiated research to explore how health data exchange can reduce health care costs and improve affordability. With new legislation under consideration to strengthen governance for the Data Exchange Framework, CHCF sought timely insights to guide strategy and investment. The goal is to…

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Manifest MedEx Adds Health-Related Social Services (HRSS) Information to Its Claims and Clinical Data Exchange Network

Social services organizations can now join California’s largest nonprofit health data network to better coordinate whole person care with local hospitals and health plans RIVERSIDE, Calif.–(BUSINESS WIRE)–Manifest MedEx (MX) announced today that health-related social services (HRSS) organizations can now connect and exchange health and HRSS information through its nonprofit health data network to help those experiencing…

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California Health Data Utility Manifest MedEx’s Increasing Role in Public Health

In 2022 MX began supporting the California Department of Public Health with the infrastructure required to enable statewide electronic lab reporting During a WEDI 2025 Spring Conference panel session, Erica Galvez, CEO of Manifest MedEx (MX), highlighted several ways the health data utility (HDU) is partnering with state and local public health agencies in California…

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“The Future of Health Data Sharing: A Story of Headwinds, Tailwinds, and Unknowns” Webinar Recap

From the future of TEFCA to the potential impact of Medicaid reform, there are opportunities, challenges, and unknowns that affect the seamless, secure exchange of health and social services information at both the state and national levels. Watch below for a candid, in-depth conversation from health data experts around the future of health data sharing.…

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Manifest MedEx Designated a Qualified Health Information Organization (QHIO) in the California Health and Human Services Data Exchange Framework

California’s largest nonprofit health data network qualified by state to support health organizations in meeting data sharing requirements by January 2024 deadline. Emeryville, Calif. – (BUSINESS WIRE) – Manifest MedEx (MX), California’s largest nonprofit health information organization (HIO), announced today that its application as a Qualified Health Information Organization (QHIO) in the California Health and…

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Optimizing and Streamlining HEDIS® Reporting With Health Information Exchange Data

How an innovative health plan saves time and improves quality scores with data from Manifest MedEx As part of its quality improvement efforts, Health Plan of San Joaquin uses HEDIS® to measure performance and gauge quality and effectiveness of care provided to their members. Developed and maintained by NCQA, the performance measures in HEDIS® are related to…

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Incentivizing Data Sharing Among Health Plans, Hospitals, and Providers To Improve Quality

Health plans can gain efficiencies and improve quality by connecting to health information networks and incentivizing hospital and provider participation as part of pay-for-performance programs. Health plans, hospitals, and providers are increasingly recognizing that sharing claims and clinical data can help them coordinate care, reduce costs, manage population health, improve patient experience and outcomes, and…

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Choice Medical Group Leverages Longitudinal Patient Records from Manifest MedEx to Succeed Under Full-Risk Value-Based Care Model

Founded more than 30 years ago, Choice Medical Group (CMG) is a primary care and multi-specialty medical group and independent practice association (IPA) serving the High Desert community in San Bernardino County. The group is comprised of more than 200 physicians, four inclusive facilities, and 12 local urgent care facilities. Operating on an employed model…

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Our Network

Join more than 3200+ California healthcare organizations, including over 140+ hospitals, 19 health plans, and results from LabCorp, Quest, and Radnet.

Ready to learn more about Manifest MedEx?

We are California’s largest nonprofit health data network and a designated qualified health information organization (QHIO) in the CalHHS Data Exchange Framework — actively monitoring, delivering and integrating patient data in or near real-time across a diverse network of data contributors — to provide healthcare organizations with the information they need to improve care, enhance health, and lower costs.